Weekly mileage and heart disease risk factors

Physical activity appears to reduce the risk of heart disease in women. The reduction may be due in part to higher levels of high density lipoprotein (HDL) cholesterol. In women, high plasma levels of HDL-cholesterol appear to help prevent heart attacks. Our objective was to determine how vigorous exercise can improve HDL and other coronary heart disease risk factors. This was done by comparing physician-supplied medical data to reported distance ran per week in a national cross-sectional survey of 1,837 women
HDL in females graph.

recreational runners. All had completed a two-page questionnaire as part of their participation in the National Runners' Health Study.

The graph at lower left shows that HDL cholesterol (the good cholesterol) increased significantly with each 10 mile increment in running mileage up to 40 miles per week. HDL-cholesterol increased significantly in premenopausal women not using oral contraceptives, in postmenopausal women not taking estrogen replacement, and in postmenopausal women taking estrogen replacement. In women using birth control pills the results were less clear.

Body mass index (BMI) is a measure of a person's weight compared to their height. It is widely used in epidemiological studies when a direct measurement of a person's fat is not available. It is calculated as weight (in kilograms) divided by the square of a person's height (in meters). A BMI of 25 or less is desirable, 25-30 is moderately overweight, and 30 or more is considered severely overweight. The graph on the following page shows that women who ran a greater weekly distance were leaner.